Why fet fails

Many couples will have a successful second IVF. The chances for that happening depends on many factors, including: Age of the female partner Egg quality and egg quantity Sperm quality Quality of the IVF ovarian stimulation — dependent on the skills of the physician controlling this process IVF lab quality Egg retrieval skills of the physician and overall efficiency of the egg pickup process Embryo transfer skills of your IVF doctor and ultrasound equipment and technician Number of eggs retrieved The cause of your infertility Uterine issues Embryo developmental rates , embryo quality, and rates of embryonic arrest during development in the lab Genetic and chromosomal competence of the embryos In order to maximize the chances for a successful second IVF try make sure that your doctor has carefully reviewed the issues above.

Prev Previous. Next Next. Share on facebook. Share on twitter. Share on linkedin. Related Articles. Varicoceles in Men and Infertility When should surgery be done? Numerous sperm — at high magnification on a counting chamber. Advanced Fertility Center of Chicago. Fertility BLOG.

Higher Standards - Proven Results. Read More. Fertility Care. Imagine a farmer who owns a piece of land and wants to cultivate rice.

He ploughs and tills the land, making it ready for sowing, finds the right season, and carefully selects the seeds. Hormones estrogen and progesterone are also used make the uterus ready for accepting the embryo just like ploughing the land, adding fertilizers and so on.

The woman needs to be in good health analogous to waiting for the right season to sow the seeds. When a farmer takes care of all these things and sows the seeds, he expects the seeds to germinate and grow. But what happens when the seeds fail to sprout? There are three main reasons for this happening:. In rare cases, additional factors which prevent growth include improper seeding difficult or traumatic embryo transfer , or a sudden change to the environment e. It is a well-known fact that young women fall pregnant quickly when compared to their older counterparts.

This is because eggs from older women are more prone to genetic defects, such as aneuploidies presence of the wrong number of chromosomes , and contain incorrect or insufficient genetic information necessary to build a healthy baby.

When such eggs are fertilized, it leads to the generation of embryos which are genetically incompetent. Either such embryos do not implant and even if they do, the pregnancy ends in early miscarriage. In rare instances, they can also lead to a full-term birth where the newborn has genetic defects.

With the advent of comprehensive chromosome screening, it is now possible to screen all 24 chromosomes 22 autosomes and 2 sex chromosomes for the presence of aneuploidy even though the effectiveness of such a technique to increase live birth via ART in clinical practice is still not proven.

This clearly shows that embryo competency plays a major role in implantation. This is why older women require more attempts than their younger counterparts to succeed with IVF. When an older woman uses donor eggs, her chance of achieving IVF success goes up dramatically! This is irrefutable proof that it is embryo quality which plays a major role in implantation and IVF success. The importance of soil quality in agriculture is well known. Does endometrium play such a crucial role in embryo implantation?

What happens when a fertile seed genetically competent embryo is seeded on defective soil non-receptive endometrium? In humans, the receptivity period is between day 20 to day 24 of regular menstrual cycle i. You can calculate the best time for you to get pregnant with this easy-to-use fertility calendar.

During frozen embryo transfer , the day of starting progesterone is taken as the first day of ovulation and embryo transfer is done accordingly.

Human embryo implantation is an enigmatic biological phenomenon — after all, in-vivo experiments are impractical and unethical to conduct; and studies with animal models do not translate well to humans. But it is well-known fact that embryo and endometrium talk to each other using molecular signals, and such cross-talk is necessary for successful implantation.

However, no reliable molecular markers for endometrial receptivity have been identified. This makes it difficult to find out whether the endometrium is receptive or not during an IVF cycle. During IVF, endometrial receptivity is assessed crudely with the help of ultrasound images.

Endometrial thickness is measured using ultrasound images, and an endometrium of greater than 8mm, which is trilaminar, is believed to be optimum for embryo transfer. It is a well-known fact that the endometrium becomes receptive only after progesterone exposure.

Progesterone brings about necessary changes in endometrium converts the endometrium from proliferative to secretory phase so that it becomes ready to accept the embryo. Recently, frozen embryo transfers are becoming much more successful than fresh embryo transfers in the field of IVF. For more information or to simply talk to a member of the Nurture Fertility team, get in touch today by giving us a call on or via our contact page. Schedule an appointment to start your fertility journey with us.

Apr 3, The Quality of the Embryo. The Age of the Eggs. Response from Ovaries. Did you like this article? As the value of the ERA test for improving pregnancy rates has not been proven, please note that this test is not approved for use in all states and is not considered standard of care. For many couples, many if not most embryos created in an IVF cycle have an abnormal number of chromosomes. Transfer of abnormal embryos results in failure to conceive, or increased rates of miscarriage and abnormal births.

PGT-A is a procedure in which cells are removed from a developing embryo and are tested for chromosome content. Embryos that have a normal complement of chromosomes are selected for embryo transfer, resulting in improved pregnancy rates and reduced miscarriage rates. Furthermore, PGT-A improves the ability to achieve pregnancy with single embryos, which reduces the risks related to multiple pregnancy faced by mothers and babies.

Feinman usually incorporates PGT-A, along with some of the other tests, on an individualized basis. Couples do need to understand, however, that a small amount of error does exist in the technologies used for embryo biopsy and chromosome testing.